Given the growing evidence of a link between cupless bra pattern gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal microbiota transplantation (FMT), aimed at rebuilding GM, has been proposed as a new therapeutic approach to MS treatment.To evaluate the viability of FMT for MS treatment and its impact on MS pathology, we tested FMT in mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of MS.We provide evidence that FMT can rectify altered GM to some extent with a therapeutic effect on EAE.We also found that FMT domeless quartz nails led to reduced activation of microglia and astrocytes and conferred protection on the blood-brain barrier (BBB), myelin, and axons in EAE.
Taken together, our data suggest that FMT, as a GM-based therapy, has the potential to be an effective treatment for MS.